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1. obstacle; impediment; hindrance; difficulty; barrier

2. handicap; impairment; disability; disorder; malfunction  (see also: 視力障害; this meaning is restricted to reading しょうがい)

to hinder; to interfere with; to affect; to do one harm; to be harmful to

hard (on the ears); offensive (to the ear); rasping; rough; harsh; grating; jarring; cacophonous